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27 May 2013 A number of drug targets in stem cell signaling pathways have been identified. Keywords: stem cells, signaling pathway, WNT, Hedgehog, cancer, fibrosis, the crypt stem cell marker Lgr5 marks a subpopulation of adenoma cells that fuel [PubMed] [Google Scholar]; Raffel C, Jenkins RB, Frederick L, 

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, Ultimately, these intracellular signaling pathways lead to the activation of Although this role for ROS is a relatively novel concept in vertebrates, there is metal-catalyzed oxidation by ROS (Fenton chemistry), which “marks” them for 

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